Accordion content 1.

1. Thalidomide and its analogs differentially target Fibroblast Growth Factor Receptors: Thalidomide suppresses FGFR gene expression while pomalidomide dampens FGFR2 activity
Name of the Authors : L Sundaresan, P Kumar, J Manivannan, S Chatterjee
Chemical Research in Toxicology 32 (4), 589-602 (2019).

2.A proteome-wide systems toxicological approach deciphers the interaction network of chemotherapeutic drugs in the cardiovascular milieu
Name of the Authors : S Giri, J Manivannan, B Srinivasan, S Chatterjee.
RSC Advances 8, 20211-20221(2018)

3.Transcriptomic analysis of thalidomide challenged chick embryo suggests possible link between impaired vasculogenesis and defective organogenesis
Name of the Authors :V Veeriah, P Kumar, L Sundaresan, Z Mafitha, J.Manivannan, S.Chattejee
Chemical Research in Toxicology 30 (10), 1883-1896 (2017).

4. A novel liquid chromatography/tandem mass spectrometry (LC–MS/MS) based bioanalytical method for quantification of ethyl esters of Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) and its application in pharmacokinetic study
Name of the Authors :S Viswanathan, PRP Verma, MGanesan, J Manivannan.
J Pharm Biomed Anal.141:250-261 (2017)

5.Oxidative environment causes molecular remodeling in embryonic heart-a metabolomic and lipidomic fingerprinting analysis
Name of the Authors :S Manickaraj, D Thirumalai, P Manjunath P, V Sekarbabu, Jeganathan M.
Life Science Archives 3 (2), 981-985(2017)

6.Environmental endocrine disrupting chemicals (EDCs) and its systems level toxicological mechanisms – an environmental health study
Name of the Authors :J Manivannan and S Usha
J Pharm Biomed Anal.141:250-261 (2017)

7.Disturbed flow mediated modulation of shear forces on endothelial plane: a proposed model for studying endothelium around atherosclerotic plaques
Name of the Authors :UM Balaguru, L Sundaresan, J Manivannan, R Majunathan, S Chatterjee
Scientific Reports 6 (1), 1-15 (2016)

8.Prevention of cardiac dysfunction, kidney fibrosis and lipid metabolic alterations in l-NAME hypertensive rats by sinapic acid—Role of HMG-CoA reductase
Name of the Authors : T Silambarasan, J Manivannan, B Raja, S Chatterjee
European Journal of Pharmacology 777, 113-123 (2016)
 

9.Systems biological understanding of the regulatory network and the possible therapeutic strategies for vascular calcification
Name of the Authors :J Manivannan, M Prashanth, VS Kumar, M Shairam, J Subburaj
Molecular BioSystems 12 (12), 3683-3694 (2016)

10.Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation
Name of the Authors :M Saravanakumar, B Raja, J Manivannan, T Silambarasan
British Journal of Nutrition 114 (9), 1385-1394 (2015)

11.Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress
Name of the Authors :T Silambarasan, J Manivannan, MK Priya, N Suganya, S Chatterjee, B Raja
Biochemical and Biophysical Research Communications 456 (4), 853-859 (2015) DOI: )

12.Systems pharmacology and molecular docking strategies prioritize natural molecules as cardioprotective agents
Name of the Authors :J Manivannan, T Silambarasan, R Kadarkarairaj, B Raja
RSC Advances 5 (94), 77042-77055 (2015)

13.Diosgenin, a steroidal saponin, prevents hypertension, cardiac remodeling and oxidative stress in adenine induced chronic renal failure rats
Name of the Authors :J Manivannan, J Shanthakumar, T Silambarasan, E Balamurugan, B Raja
RSC Advances 5 (25), 19337-19344 (2015)

14.Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats
Name of the Authors :T Silambarasan, J Manivannan, MK Priya, N Suganya, S Chatterjee, B Raja PloS one 9 (12), e115682 (2014)

15.Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion
Name of the Authors :O Senthamizhselvan, J Manivannan, T Silambarasan, B Raja
European Journal of Pharmacology 736, 131-137 (2014)

16.Diosgenin interferes coronary vasoconstriction and inhibits osteochondrogenictransdifferentiation of aortic VSMC in CRF rats
Name of the Authors :J Manivannan, J Shanthakumar, P Arunagiri, B Raja, E Balamurugan
Biochimie 102, 183-187 (2014)
 

17.Valproic acid attenuates blood pressure, vascular remodeling and modulates ET-1 expression in L-NAME induced hypertensive rats
Name of the Authors :T Rajeshwari, B Raja, J Manivannan, T Silambarasan
Biomedicine and Preventive Nutrition 4 (2), 195-202 (2014)

18.Valproic acid prevents the deregulation of lipid metabolism and renal renin–angiotensin system in l-NAME induced nitric oxide deficient hypertensive rats
Name of the Authors :T Rajeshwari, B Raja, J Manivannan, T Silambarasan, T Dhanalakshmi Environmental Toxicology and Pharmacology 37 (3), 936-945 (2014)

19.In Silico Sequence Analysis Homology Modelling and Functional Annotation of Toxin I Hypothetical Protein of Catfish Plotosuslineatus
Name of the Authors :T. R. Barathkumar, J Manivannan, MThangaraj
International Journal of Pharmaceutical & Biological Archives; 4(4): 753 – 757(2013)

20.Effect of diosgenin on cardiac tissue lipids, trace elements, molecular changes, TNF-α and IL-6 expression in CRF rats
Name of the Authors :J Manivannan, J Shanthakumar, K Rajeshwaran, P Arunagiri, E Balamurugan
Biomedicine & Preventive Nutrition 3 (4), 389-392 (2013)

21.Diosgenin improves vascular function by increasing aortic eNOS expression, normalize dyslipidemia and ACE activity in chronic renal failure rats
Name of the Authors :J Manivannan, E Balamurugan, T Silambarasan, B Raja
Molecular and Cellular Biochemistry 384 (1), 113-120 (2013)

22.Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular alterations in chronic renal failure rats
Name of the Authors :J Manivannan, P Arunagiri, J Sivasubramanian, E Balamurugan
International Journal of Nutrition, Pharmacology, Neurological Diseases; 3:289-93 (2013)
 

23.Determination of aluminium induced metabolic changes in mice liver: A Fourier transform infrared spectroscopy study
Name of the Authors :S Sivakumar, J Sivasubramanian, CP Khatiwada, J Manivannan, B Raja
SpectrochimicaActa Part A: Molecular and Biomolecular Spectroscopy 110, 241-248 (2013) 

24.Diosgenin attenuates vascular calcification in chronic renal failure rats
Name of the Authors :J Manivannan, TR Barathkumar, J Sivasubramanian, P Arunagiri, B Raja, E Balamurugan
Molecular and cellular biochemistry 378 (1), 9-18 (2013)

25.Computational systems biology of oxLDL induced macrophage foam cellformation-A multilayer regulatory network analysis of atherogenic process
Name of the Authors :M Prashanth, J Manivannan, T Silambarasan, E.Balamurugan
Journal of Chemical and Pharmaceutical Research; 5(10):39-44 (2013) )

26.Computational systems pharmacology and docking explored diosgenin targets causal and effectors pathogenic signalling network of vascular calcification
Name of the Authors :J Manivannan, TRB Kumar, P Arunagiri, E Balamurugan
J. Chem. Pharm. Res 5, 161-167 (2013) )

27.Aluminium induced metabolic changes in kidney and heart tissue of mice: a Fourier transform infrared spectroscopy study
Name of the Authors :S Sivakumar, J Sivasubramanian, J Manivannan, B Raja
RSC Advances 3 (43), 20896-20904 (2013)

28.Molecular metabolic fingerprinting approach to investigate the effects of borneol on metabolic alterations in the liver of nitric oxide deficient hypertensive rats
Name of the Authors :M Saravanakumar, J Manivannan, J Sivasubramanian, T Silambarasan, B Raja
Molecular and cellular biochemistry 362 (1), 203-209 (2012)

29.Evaluation of in vitro antioxidant and antimicrobial potential of methanolic leaf extract of Anisomelesmalabarica (Linn.).
Name of the Authors :B Raja, J Manivannan
Journal of Pharmacy Research 3 (7), 1471-1474 (2010)